Mutations defining functional regions of the superantigen staphylococcal enterotoxin B.
نویسندگان
چکیده
منابع مشابه
Mutations defining functional regions of the superantigen staphylococcal enterotoxin B
Staphylococcal enterotoxin B (SEB) is both a superantigen and toxin. As a superantigen, SEB can bind to major histocompatibility complex (MHC) class II molecules to form a ligand for alpha/beta T cell receptors bearing particular V beta elements. As a toxin, SEB causes rapid weight loss in mice sometimes leading to death. We show here that both of these functions map to the NH2-terminal portion...
متن کاملMutations Defining Functional Regions of the Superantigen Staphylococcal Enterotoxin
Staphylococcal enterotoxin B (SEB) is both a superantigen and toxin. As a superantigen, SEB can bind to major histocompatibility complex (MHC) class II molecules to form a ligand for ot/B T cell receptors bearing particular VB elements. As a toxin, SEB causes rapid weight loss in mice sometimes leading to death. We show here that both of these functions map to the NH2-terminal portion of the to...
متن کاملMutations Defining Functional Regions of the Superantigen Staphylococcal Enterotoxin B By
Staphylococcal enterotoxin B (SEB) is both a superantigen and toxin. As a superantigen, SEB can bind to major histocompatibility complex (MHC) class II molecules to form a ligand for ot/B T cell receptors bearing particular VB elements. As a toxin, SEB causes rapid weight loss in mice sometimes leading to death. We show here that both of these functions map to the NH2-terminal portion of the to...
متن کاملAssessment of the Functional Regions of the Superantigen Staphylococcal Enterotoxin B
The functional activity of superantigens is based on capacity of these microbial proteins to bind to both the β-chain of the T cell receptor (TcR) and the major histocompatibility complex (MHC) class II dimer. We have previously shown that a subset of the bacterial superantigens also binds to a membrane protein, designated p85, which is expressed by renal epithelial cells. This binding activity...
متن کاملMonoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B
Four monoclonal antibodies (mAbs) were produced binding to four nonoverlapping epitopes on the superantigen staphylococcal enterotoxin B (SEB). The mAbs were tested for their ability to detect SEB bound to major histocompatibility complex (MHC) class II, to inhibit SEB binding to MHC class II, to inhibit SEB stimulation of T cell hybridomas, to bind to various nonfunctional mutants of SEB, and ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1992
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.175.2.387